A national retail chain needs to design an IP addressing scheme to support a nationwide network. The company needs a minimum of 300 sub-networks and a maximum of 50 host addresses per subnet. Working with only one Class B address, which of the following subnet masks will support an appropriate addressing scheme? （）

A.255.255.255.0
B.255.255.255.128
C.255.255.252.0
D.255.255.255.224
E.255.255.255.192
F.255.255.248.0